Cancer metastasis is resistant to current therapies and responsible for more than 90% of cancer-related deaths. Our primary mission is to determine unknown mechanisms of cancer metastasis from the view of bio-physics to prevent metastasis.
Interactions of metastasized cancer cells and the microenvironment in various metastatic organs can create complexed tumor heterogeneities. These tumor heterogeneities can constitute a major source of therapeutic resistance. Our second mission is to understand the driving forces behind these tumor heterogeneities to improve therapeutic efficacy.
The SATB2-associated syndrome is recently identified very rare genetic disease in children to cause neurological disorders. Our third mission is to identify molecular mechanisms of the consequences of the genetic mutations in neurons to develop potential gene therapy.